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HRID543865

反应详情

EQUATION

反应方程式

HRID 543865 的结构方程式

REACTANTS

反应物

2
结构：NC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O)[C@H](N)C[C@@H]2N)[C@H](O)[C@@H](O)[C@@H]1O
HCID6032

Kanamycin A

C18H36N4O11

结构：NCC[C@H](O)C(=O)N[C@@H]1C[C@H](N)[C@@H](O[C@H]2O[C@H](CN)[C@@H](O)[C@H](O)[C@H]2O)[C@H](O)[C@H]1O[C@H]1O[C@H](CO)[C@@H](O)[C@H](N)[C@H]1O.O=S(=O)(O)O
HCID5458175

未命名化合物

PRODUCTS

生成物

1
结构：NCC[C@H](O)C(=O)N[C@@H]1C[C@H](N)[C@@H](O[C@H]2O[C@H](CN)[C@@H](O)[C@H](O)[C@H]2O)[C@H](O)[C@H]1O[C@H]1O[C@H](CO)[C@@H](O)[C@H](N)[C@H]1O
HCID37768

Amikacin

C22H43N5O13

AUXILIARIES

试剂、催化剂与溶剂

1
结构：O
溶剂HCID962

Water

H2O

PROCEDURE

实验过程

Amikacin sulfate is a water-soluble, broad spectrum, semisynthetic aminoglycoside antibiotic derived from kanamycin, which is obtained from Streptomyces kanamyceticus. In normal adults, average peak serum concentrations of about 12, 16 and 21 μg/ml are obtained about 1 hour after intramuscular administration of 3.7 mg/kg, 5 mg/kg, and 7.5 mg/kg single doses, respectively. Normal dosage is 15 mg/kg daily, divided into 2-3 equal doses.

WORKUP

后处理

  1. customIn normal adults, average peak serum concentrations of about 12, 16 and 21 μg/ml are obtained about 1 hour after intramuscular administration of 3.7 mg/kg, 5 mg/kg, and 7.5 mg/kg single doses