Kanamycin → Amikacin

Participants

Reaction Steps

Amikacin sulfate is a water-soluble, broad spectrum, semisynthetic aminoglycoside antibiotic derived from kanamycin, which is obtained from Streptomyces kanamyceticus. In normal adults, average peak serum concentrations of about 12, 16 and 21 μg/ml are obtained about 1 hour after intramuscular administration of 3.7 mg/kg, 5 mg/kg, and 7.5 mg/kg single doses, respectively. Normal dosage is 15 mg/kg daily, divided into 2-3 equal doses.

Provenance & Evidence