4-Bromoanisole → 3-Bromoanisole

HRID 543913Notes

Reaction equation

HRID 543913 reaction equation
Br[C:2]1[CH:7]=[CH:6][C:5]([O:8][CH3:9])=[CH:4][CH:3]=1.[Br:10]C1C=C(O)C=CC=1>>[Br:10][C:3]1[CH:4]=[C:5]([O:8][CH3:9])[CH:6]=[CH:7][CH:2]=1

Participants

4

Reactant 3

HCID 77304-BromoanisoleHCID 115633-BromophenolHCID 178506046HCID 178506046, compound

Product 1

HCID 169713-BromoanisoleYield 40%

Procedure

2.9 mmol of parabromo-anisole and 15 cm3 of 1.7 M HF--SbF5 superacid are contacted for 55 hours at ambient temperature in a poly(tetrafluoroethylene) container. Chromatographic analysis of the reaction products shows that a mixture of meta-bromo-phenol (25%) and meta-bromoanisole (40%) is formed, in a 65% yield.

Sources & evidence

ORD record
ord-92f2a33246254553a8d63aebdf918127
Source dataset
uspto-grants-1984_05
Patent number
US04447660

Reaction notes

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