反应详情

温度

60 °C

A mixture of 14.8 g (0.1 mole) of phthalic anhydride, 16.3 g (0.1 mole) of 100 percent 3-pyrrolidinophenol and 50.0 ml of 1,2-dichloroethane was maintained at approximately 40° C. for approximately twenty-four hours, at approximately 60° C. for approximately twenty-four hours and at reflux temperature for approximately twelve hours. After cooling the reaction mixture to ambient temperature, the solid which precipitated was collected by filtration and washed with 500.0 ml of 1,2-dichloroethane. The solid was dissolved in dilute aqueous soduim hydroxide, the resulting mixture was filtered to remove insolubles. The filtrate was adjusted to pH 7.0 with the addition of glacial acetic acid and the solid tar-like material which formed was collected by filtration. To the filtrate an additional amount of glacial acetic acid was added. The solid which precipitated was collected by filtration, washed with water and dried to obtain 11.3 g of 2-(2-hydroxy-4-pyrrolidinophenyl)carbonylbenzoic acid, a pale pink-colored solid which melted at 190°-192° C. To the filtrate there was added an additional portion of glacial acetic acid and the solid which was collected by filtration, washed with water and dried to obtain 0.3 g a pale yellow-colored crystals of the desired product which melted at 193°-195° C. The infrared spectra of the two solids were identical having significant maxima at 1100 cm-1 (C=O;m). The nuclear magnetic spectra were consistent with the assigned structure.

1. temperatureat reflux temperature for approximately twelve hours
2. temperatureAfter cooling the reaction mixture to ambient temperature
3. customthe solid which precipitated
4. filtrationwas collected by filtration
5. washwashed with 500.0 ml of 1,2-dichloroethane
6. dissolutionThe solid was dissolved in dilute aqueous soduim hydroxide
7. filtrationthe resulting mixture was filtered
8. customto remove insolubles
9. additionThe filtrate was adjusted to pH 7.0 with the addition of glacial acetic acid
10. customthe solid tar-like material which formed
11. filtrationwas collected by filtration
12. additionTo the filtrate an additional amount of glacial acetic acid was added
13. customThe solid which precipitated
14. filtrationwas collected by filtration
15. washwashed with water
16. customdried