Ammonia → HCID 70478162, compound

HRID 544108Notes

Reaction equation

HRID 544108 reaction equation
C([O:3][C:4](=O)[CH2:5][CH2:6][CH2:7][O:8][C:9]1[CH:14]=[CH:13][C:12]([CH3:15])=[CH:11][C:10]=1[CH2:16][C:17]1[NH:18][CH:19]=[CH:20][N:21]=1)C.[NH3:23]>>[NH:21]1[CH:20]=[CH:19][N:18]=[C:17]1[CH2:16][C:10]1[CH:11]=[C:12]([CH3:15])[CH:13]=[CH:14][C:9]=1[O:8][CH2:7][CH2:6][CH2:5][C:4]([NH2:23])=[O:3]

Participants

3

Reactant 2

HCID 222AmmoniaHCID 70478109HCID 70478109, compound

Product 1

HCID 70478162HCID 70478162, compound

Procedure

A mixture of 4-[2-(1-imidazolylmethyl)-4-methyl-phenoxy]butyric acid ethyl ester (1.0 g) and 0.880 ammonia solution was stirred for 6 hours and allowed to stand for a further 36 hours. The solid was filtered off and crystallised from water to give 4-[2-(1-imidazolylmethyl)-4-methyl-phenoxy]butyramide (0.30 g), m.p. 114°-116° C. Found: C, 65.31, H, 7.23, N, 15.13. C15H19N3O2 requires: C, 65.91, H, 7.01, N, 15.37%.

Workup

  1. waitto stand for a further 36 hours
  2. filtrationThe solid was filtered off
  3. customcrystallised from water

Sources & evidence

ORD record
ord-5954e155c3594c6ba9f4f3f238461844
Source dataset
uspto-grants-1984_05
Patent number
US04448781

Reaction notes

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