Methylamine → HCID 70478659, compound

HRID 544111Notes

Reaction equation

HRID 544111 reaction equation
C(O[C:4](=[O:19])[CH2:5][O:6][C:7]1[CH:12]=[CH:11][C:10]([CH2:13][C:14]2[NH:15][CH:16]=[CH:17][N:18]=2)=[CH:9][CH:8]=1)C.[CH3:20][NH2:21]>>[CH3:20][NH:21][C:4](=[O:19])[CH2:5][O:6][C:7]1[CH:8]=[CH:9][C:10]([CH2:13][C:14]2[NH:18][CH:17]=[CH:16][N:15]=2)=[CH:11][CH:12]=1

Participants

3

Reactant 2

HCID 6329MethylamineHCID 70456159HCID 70456159, compound

Product 1

HCID 70478659HCID 70478659, compound

Procedure

A solution of 4-(1-imidazolylmethyl)phenoxyacetic acid ethyl ester (1.02 g) in 33% ethanolic methylamine was allowed to stand for 24 hour. The solution was evaporated and the residue was crystallised from ethyl acetate/petrol to give N-methyl-4-(1-imidazolylmethyl)phenoxyacetamide (0.61 g), m.p. 124°-125° C. Found: C, 63.44, H, 6.21, N, 17.25. C13H15N3O2 requires: C, 63.66, H, 6.16, N, 17.13%.

Workup

  1. customThe solution was evaporated
  2. customthe residue was crystallised from ethyl acetate/petrol

Sources & evidence

ORD record
ord-a8f32c973d0b48338e66cdc85b8290c5
Source dataset
uspto-grants-1984_05
Patent number
US04448781

Reaction notes

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