Acetic Anhydride → HCID 20459805, compound

HRID 544205Notes

Reaction equation

HRID 544205 reaction equation
[C:1]([CH2:3][C:4]([OH:6])=O)#[N:2].[CH3:7][C:8]1[CH:13]=[CH:12][CH:11]=[C:10]([CH3:14])[C:9]=1[NH:15][NH:16][C:17]([NH2:19])=[O:18].C(OC(=O)C)(=O)C>CCOCC>[C:1]([CH2:3][C:4]([N:15]([C:9]1[C:8]([CH3:7])=[CH:13][CH:12]=[CH:11][C:10]=1[CH3:14])[NH:16][C:17]([NH2:19])=[O:18])=[O:6])#[N:2]

Participants

5

Reactant 3

HCID 7918Acetic AnhydrideHCID 9740Cyanoacetic acidHCID 13326262HCID 13326262, compound

Product 1

HCID 20459805HCID 20459805, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

A mixture of 1 mole of cyanoacetic acid, 1 mole of 1-(2,6-dimethylphenyl)semicarbazide and 300 ml of acetic anhydride is heated to 80° for 2 hours. The mixture is cooled to RT, 50 ml of ether is added and it is stirred at RT overnight. The reaction mixture is filtered, washed with ether (3X) and dried to give N-(2-cyanoacetyl)-1-(2,6-dimethylphenyl)semicarbazide.

Workup

  1. temperatureis heated to 80° for 2 hours
  2. filtrationThe reaction mixture is filtered
  3. washwashed with ether (3X)
  4. customdried

Sources & evidence

ORD record
ord-4cd92fd3a7b34398bb2c605dbe80bad5
Source dataset
uspto-grants-1984_05
Patent number
US04448961

Reaction notes

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