Hydrochloric Acid → HCID 20459852, compound

HRID 544212Notes

Reaction equation

HRID 544212 reaction equation
C[O:2][C:3]1[S:4][C:5]([CH2:8][O:9][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)=[N:6][N:7]=1.Cl>O1CCOCC1>[O:9]([CH2:8][C:5]1[S:4][C:3](=[O:2])[NH:7][N:6]=1)[C:10]1[CH:11]=[CH:12][CH:13]=[CH:14][CH:15]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 20459851HCID 20459851, compound

Product 1

HCID 20459852HCID 20459852, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

44 g of crude 2-methoxy-5-phenoxymethyl-1,3,4-thiadiazole are added in portions to a solution of 15 g of hydrogen chloride in 200 ml of dioxane. After boiling for one hour under reflux, the mixture is evaporated and the resulting mass is recrystallised from a little methanol. This gives 30 g of 5-phenoxymethyl-1,3,4-thiadiazol-2(3H)-one as colourless crystals.

Workup

  1. temperatureunder reflux
  2. customthe mixture is evaporated
  3. customthe resulting mass is recrystallised from a little methanol

Sources & evidence

ORD record
ord-2c84cc34aeef453098a64dc1191d9ee0
Source dataset
uspto-grants-1984_05
Patent number
US04448968

Reaction notes

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