Tributyltin Chloride → HCID 88379466, compound

HRID 54425Notes

Reaction equation

HRID 54425 reaction equation
[Cl:1][C:2]1[N:3]=[N:4][C:5]([Cl:8])=[CH:6][CH:7]=1.CC1CCCN(C)C1(C)C.[Li].[CH2:20]([Sn:24](Cl)([CH2:29][CH2:30][CH2:31][CH3:32])[CH2:25][CH2:26][CH2:27][CH3:28])[CH2:21][CH2:22][CH3:23]>C1COCC1>[CH2:29]([SnH:24]([CH2:20][CH2:21][CH2:22][CH3:23])[CH2:25][CH2:26][CH2:27][CH3:28])[CH2:30][CH2:31][CH3:32].[Cl:1][C:2]1[N:3]=[N:4][C:5]([Cl:8])=[CH:6][CH:7]=1

Participants

5

Reactant 3

HCID 15096Tributyltin ChlorideHCID 673313,6-DichloropyridazineHCID 66701855Lithium tetramethylpiperidine

Product 1

HCID 88379466HCID 88379466, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent2×

Procedure

A THF solution (10 mL) of 3,6-dichloropyridazine (16.8 mmol, 2.5 g) was added dropwise to a solution of lithium tetramethylpiperidine (20.1 mmol) in 170 mL of THF at -78° C. After one hour at -78° C., tributyltin chloride (21.8 mmol, 5.8 mL) was added to the anion solution and the solution was allowed to warm slowly overnight.

Workup

  1. temperatureto warm slowly overnight

Sources & evidence

ORD record
ord-7f7b3066bbb14fee89758dd2e71988a4
Source dataset
uspto-grants-1997_04
Patent number
US05622967

Reaction notes

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