反应详情

A THF solution (10 mL) of 3,6-dichloropyridazine (16.8 mmol, 2.5 g) was added dropwise to a solution of lithium tetramethylpiperidine (20.1 mmol) in 170 mL of THF at -78° C. After one hour at -78° C., tributyltin chloride (21.8 mmol, 5.8 mL) was added to the anion solution and the solution was allowed to warm slowly overnight.

1. temperatureto warm slowly overnight