反应详情

A mixture of 12.9 g of 2-piperidine methanol, 13.2 g of benzyl chloride, 10.5 g of triethylamine and 50 ml of toluene was stirred at reflux for 4 hours. The reaction mixture was filtered, the filtrate was concentrated, and the concentrate was distilled under reduced pressure to obtain 11.3 g of 1-benzyl-2-piperidine methanol (yield: 52.9%). b.p.: 107° C./2 mmHg

1. temperatureat reflux for 4 hours
2. filtrationThe reaction mixture was filtered
3. concentrationthe filtrate was concentrated
4. distillationthe concentrate was distilled under reduced pressure