HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diketene → acetoacetic acid-(N-benzyl-3-piperidinylmethyl) ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diketene | HCID 12661 | — |
| Reactant | (1-Benzylpiperidin-3-yl)methanol | HCID 10398044 | — |
| Product | acetoacetic acid-(N-benzyl-3-piperidinylmethyl) ester | HCID 54025251 | 82.7% |
Reaction Steps
In this reference example, 15.01 g of 1-benzyl-3-piperidine methanol and 6.76 g of diketene were reacted similarly as in Reference Example 1, and the reaction product was purified by silica gel column chromatography (eluent:n-hexane:ethyl acetate=1:1 v/v), to obtain 17.50 g of acetoacetic acid-(N-benzyl-3-piperidinylmethyl) ester (yield: 82.5%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04448964 |
| Source dataset | uspto-grants-1984_05 |
| ORD ID | ord-d2e2489f285c4e58aa0693860bce2fe7 |
| Source note | uspto-grants-1984_05 |