Tetrahydrofuran → HCID 13092004, compound

HRID 544287Notes

Reaction equation

HRID 544287 reaction equation
Cl.[F:2][C:3]1[CH:4]=[CH:5][C:6]([O:16][CH3:17])=[C:7]([CH:9]([OH:15])[C:10](=[NH:14])[O:11]CC)[CH:8]=1.[O:18]1CCC[CH2:19]1>C1(C)C=CC=CC=1>[F:2][C:3]1[CH:4]=[CH:5][C:6]([O:16][CH3:17])=[C:7]([CH:9]2[O:15][C:19](=[O:18])[NH:11][C:10]2=[O:14])[CH:8]=1

Participants

4

Reactant 2

HCID 8028TetrahydrofuranHCID 13091962HCID 13091962, compound

Product 1

HCID 13092004HCID 13092004, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

By the procedure of Example 9, ethyl 1-(5-fluoro-2-methoxyphenyl) -1-hydroxymethanecarboximidate hydrochloride (9.9 g.) in 500 ml. of tetrahydrofuran was converted to toluene recrystallized 5-(5-fluoro-2-methoxyphenyl)oxazolidine-2,4-dione (5.12 g., 60%; m.p. 186°-188° C.; m/e 225).

Workup

  1. customrecrystallized 5-(5-fluoro-2-methoxyphenyl)oxazolidine-2,4-dione (5.12 g., 60%; m.p. 186°-188° C.; m/e 225)

Sources & evidence

ORD record
ord-5023bef87051462b985e3aef79fd596a
Source dataset
uspto-grants-1984_05
Patent number
US04448971

Reaction notes

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