Dimethylcarbamoyl Chloride → 5-(5-Chloro-2-methoxyphenyl)-3-ethoxycarbonyloxazolidine-2,4-dione

HRID 544316Notes

Reaction equation

HRID 544316 reaction equation
Cl[C:2]([O:4][CH2:5][CH3:6])=[O:3].CN(C)C(Cl)=O.[Cl:13][C:14]1[CH:15]=[CH:16][C:17]([O:27][CH3:28])=[C:18]([CH:20]2[O:24][C:23](=[O:25])[NH:22][C:21]2=[O:26])[CH:19]=1.[Na].ClC1C=CC(OC)=C(C2OC(=O)N(C(=O)N(C)C)C2=O)C=1>>[Cl:13][C:14]1[CH:15]=[CH:16][C:17]([O:27][CH3:28])=[C:18]([CH:20]2[O:24][C:23](=[O:25])[N:22]([C:2]([O:4][CH2:5][CH3:6])=[O:3])[C:21]2=[O:26])[CH:19]=1

Participants

5

Reactant 4

HCID 6598Dimethylcarbamoyl ChlorideHCID 10928Ethyl chloroformateHCID 20459938HCID 20459938, compoundHCID 70501325HCID 70501325, compound

Product 1

HCID 130935375-(5-Chloro-2-methoxyphenyl)-3-ethoxycarbonyloxazolidine-2,4-dione

Procedure

By the same method, but replacing ethyl chloroformate with an equivalent amount of dimethylcarbamoyl chloride, sodium 5-(5-chloro-2-methoxyphenyl)oxazolidine-2,4-dione is converted to 5-(5-chloro-2-methoxyphenyl)-3-dimethylcarbamoyloxazoldine-2,4-dione.

Sources & evidence

ORD record
ord-f8e3e9867f524f0383d28d9c9276cac4
Source dataset
uspto-grants-1984_05
Patent number
US04448971

Reaction notes

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