HCID 14234525, compound → HCID 70511443, compound

HRID 544373Notes

Reaction equation

HRID 544373 reaction equation
C(OC([N:8]1[CH2:24][CH2:23][CH2:22][C@H:9]1[C:10]([NH:12][CH2:13][CH2:14][CH2:15][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)=[O:11])=O)(C)(C)C.C(OCC)(=O)C.[ClH:31]>>[ClH:31].[C:16]1([CH2:15][CH2:14][CH2:13][NH:12][C:10](=[O:11])[C@@H:9]2[CH2:22][CH2:23][CH2:24][NH:8]2)[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=1

Participants

3

Reactant 2

HCID 14234525HCID 14234525, compoundHCID 21866389Hydrogen chloride-ethyl acetate

Product 1

HCID 70511443HCID 70511443, compound

Procedure

A solution of 1-(tert-butyloxycarbonyl)-N-(3-phenylpropyl)-L-prolinamide (2.88 g.) in ethyl acetate-hydrogen chloride (3.9 N, 30 ml.) was stirred at room temperature for one half hour, then concentrated. A solution of the residue (2.80 g.) in ethyl acetate was concentrated, affording N-(3-phenylpropyl)-L-prolinamide hydrochloride as a syrup.

Workup

  1. concentrationconcentrated
  2. concentrationA solution of the residue (2.80 g.) in ethyl acetate was concentrated

Sources & evidence

ORD record
ord-f50268dad86d45c2b881b8f81fe1a37f
Source dataset
uspto-grants-1984_05
Patent number
US04450155

Reaction notes

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