1,2-Pyrrolidinedicarboxylic acid, 1-(1,1-dimethylethyl) ester, (2S)- → HCID 52609464, compound

HRID 544374Notes

Reaction equation

HRID 544374 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:15][CH2:14][CH2:13][C@H:9]1[C:10]([OH:12])=O)=[O:7])([CH3:4])([CH3:3])[CH3:2].Cl.[CH3:17][NH:18][CH2:19][CH2:20][CH2:21][C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1>>[C:1]([O:5][C:6]([N:8]1[CH2:15][CH2:14][CH2:13][C@H:9]1[C:10]([N:18]([CH3:17])[CH2:19][CH2:20][CH2:21][C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1)=[O:12])=[O:7])([CH3:2])([CH3:3])[CH3:4]

Participants

3

Reactant 2

HCID 850831,2-Pyrrolidinedicarboxylic acid, 1-(1,1-dimethylethyl) ester, (2S)-HCID 954962830684-07-2

Product 1

HCID 52609464HCID 52609464, compound

Procedure

By the method of part A of Example 1 N-(tert-butyloxycarbonyl)-L-proline (4.3 g.) was condensed with N-methyl-3-phenylpropylamine hydrochloride (3.71 g.) and the product was purified by high pressure liquid chromatography on silica gel using hexane-ethyl acetate (3:2) as the eluant, affording 1-(tert-butyloxycarbonyl)-N-methyl-N-(3-phenylpropyl)-L-prolinamide as a syrup (2.65 g.).

Workup

  1. customthe product was purified by high pressure liquid chromatography on silica gel

Sources & evidence

ORD record
ord-145c3c6ea96c436f990872ed42b9978d
Source dataset
uspto-grants-1984_05
Patent number
US04450155

Reaction notes

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