Aniline → HCID 20458931, compound

HRID 544389Notes

Reaction equation

HRID 544389 reaction equation
[Cl:1][C:2]1[C:7]([CH3:8])=[C:6]([CH3:9])[N:5]=[CH:4][N:3]=1.[NH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1>>[ClH:1].[NH:10]([C:2]1[C:7]([CH3:8])=[C:6]([CH3:9])[N:5]=[CH:4][N:3]=1)[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1

Participants

3

Reactant 2

HCID 6115AnilineHCID 126003894-Chloro-5,6-dimethylpyrimidine

Product 1

HCID 20458931HCID 20458931, compoundYield 45.3%

Procedure

To 4.3 g (0.03 mole) of 4-chloro-5,6-dimethylpyrimidine were added 2.8 g (0.03 mole) of aniline; the mixture was then heated at 100°-150° C. for about 3 minutes. The reaction mixture quickly became a solution and soon produced a precipitate, which was collected by filtration and then recrystallised from ethanol to give 3.2 g(yield 40%) of the desired Compound No. 23, in the form of a colourless powder melting at 243°-245° C.

Workup

  1. temperaturethe mixture was then heated at 100°-150° C. for about 3 minutes
  2. customsoon produced a precipitate, which
  3. filtrationwas collected by filtration
  4. customrecrystallised from ethanol

Sources & evidence

ORD record
ord-32a4eefd906141419dc837b5919d4a2f
Source dataset
uspto-grants-1984_05
Patent number
US04450162

Reaction notes

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