4,5-Dihydro-2-thiazolamine → HCID 178479725, compound

HRID 544395Notes

Reaction equation

HRID 544395 reaction equation
[Cl:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6]([OH:17])=[C:7]([C:12]([O:14]CC)=O)[CH:8]=[N:9]2)=[CH:4][CH:3]=1.[NH2:18][C:19]1[S:20][CH2:21][CH2:22][N:23]=1>>[ClH:1].[S:20]1[CH2:21][CH2:22][N:23]=[C:19]1[NH:18][C:12]([C:7]1[CH:8]=[N:9][C:10]2[C:5]([C:6]=1[OH:17])=[CH:4][CH:3]=[C:2]([Cl:1])[CH:11]=2)=[O:14]

Participants

3

Reactant 2

HCID 156894,5-Dihydro-2-thiazolamineHCID 345422Ethyl 7-chloro-4-oxo-1,4-dihydroquinoline-3-carboxylate

Product 1

HCID 178479725HCID 178479725, compound

Procedure

Using the procedure of Example 2, ethyl 7-chloro-4-hydroxy-3-quinoline-carboxylate and 2-amino-thiazoline were reacted at reflux for 48 hours and the product was crystallized from acetic acid to obtain N-(4,5-dihydro-thiazol-2-yl)-7-chloro-4-hydroxy-3-quinoline-carboxamide hydrochloride melting at >260° C.

Workup

  1. customwere reacted
  2. temperatureat reflux for 48 hours
  3. customthe product was crystallized from acetic acid

Sources & evidence

ORD record
ord-c26c38fffa284a5ebb2ee5c624107b7f
Source dataset
uspto-grants-1984_05
Patent number
US04450166

Reaction notes

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