P-Anisidine → HCID 178492342, compound

HRID 544406Notes

Reaction equation

HRID 544406 reaction equation
[OH:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[N:5]=[C:4]([CH3:12])[C:3]=1[C:13]([O:15]CC)=O.[CH3:18][O:19][C:20]1[CH:25]=[CH:24][C:23]([NH2:26])=[CH:22][CH:21]=1>C1(C)C(C)=CC=CC=1>[OH:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[N:5]=[C:4]([CH3:12])[C:3]=1[C:13]([NH:26][C:23]1[CH:24]=[CH:25][C:20]([O:19][CH3:18])=[CH:21][CH:22]=1)=[O:15]

Participants

4

Reactant 2

HCID 7732P-AnisidineHCID 178469173HCID 178469173, compound

Product 1

HCID 178492342HCID 178492342, compound

Reagents, catalysts & solvents 1

HCID 7237O-XyleneSolvent

Procedure

Using the procedure of Example 11, ethyl 4-hydroxy-2-methyl-3-quinoline-carboxylate [described in J. Het. Chem., Vol. 16 (1979), p. 1605] and p-anisidine in xylene were refluxed for 24 hours to obtain 4-hydroxy-N-(4-methoxyphenyl)-2-methyl-3-quinoline-carboxamide melting at 222° C.

Workup

  1. temperaturewere refluxed for 24 hours

Sources & evidence

ORD record
ord-b413210405bc47f79a58efcad06be5f0
Source dataset
uspto-grants-1984_05
Patent number
US04450167

Reaction notes

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