反应详情

1-Succinimido-3-phenoxy-2-propanol (16 gm, 0.06 mole) was dissolved in 100 mL conc. HCl and 100 mL ethanol and heated to reflux for 6 hours. After the reaction, the mixture was evaporated to a white residue which was thentaken up in 25 mL water and washed with 3×50 mL ether. The aqueous phase was then evaporated and the white-residue recrystallized from ethanol to provide 8.3 gm (69%) of white crystals: mp 226°-228°. The NMR spectrum was consistent with the assignedstructure and the elemental analysis was consistent with the molecular formula C9H14NO2Cl.

1. temperatureto reflux for 6 hours
2. customAfter the reaction
3. customthe mixture was evaporated to a white residue which
4. washwashed with 3×50 mL ether
5. customThe aqueous phase was then evaporated
6. customthe white-residue recrystallized from ethanol