反应详情

A solution of 0.86 g. of 3-chloro-4-oxopentanonitrile, 0.92 g. of 2-amino-3-phenylmethoxypyridine and 0.5 ml. of triethylamine in 15 ml. of ethanol was stirred for 16 hours, then concentrated to remove the triethylamine and ethanol. The residue was dissolved in methylene chlorideand washed with water. The methylene chloride was concentrated and the residual oil was dissolved in 20 ml. of boiling acetonitrile, filtered, cooled, and treated with hydrogen chloride/methanol with cooling to give 0.22 g. of the desired product (m.p. 163°-166° C.).

1. concentrationconcentrated
2. customto remove the triethylamine and ethanol
3. dissolutionThe residue was dissolved in methylene
4. washchlorideand washed with water
5. concentrationThe methylene chloride was concentrated
6. dissolutionthe residual oil was dissolved in 20 ml
7. filtrationof boiling acetonitrile, filtered
8. temperaturecooled
9. additiontreated with hydrogen chloride/methanol
10. temperaturewith cooling
11. customto give 0.22 g