反应详情

A mixture of 8-(2-fluorobenzyloxy)3-hydroxymethyl-2-methyl-imidazo[1,2-a]pyridine from Example 5 (1 g) and phosphorylchloride (15 ml) was heated under reflux for1 hr. Excess phosphorylchloride was distilled off in vacuo, the residue dissolved in hot ethanolic HCL and the mixture filtered to give the title compound as the hydrochloride salt.

1. temperaturewas heated
2. temperatureunder reflux for1 hr
3. distillationExcess phosphorylchloride was distilled off in vacuo
4. dissolutionthe residue dissolved in hot ethanolic HCL
5. filtrationthe mixture filtered