反应详情

A suspension of 8-benzyloxy-2-methyl-imidazo[1,2-a]pyridine-3-acetamide (3 g) in dioxane was cooled to 5°-10° C. To the suspension there was added over a period of 5 minutes a solution of trifluoroacetic anhydride (6 g) in dioxane. The mixture was maintained cool and stirred for 30 minutes. Thereafter the mixture was allowed to warm to room temperature and was stirred for a further four hours. The mixture was thendiluted with ice water and the precipitate was filtered. After recrystallization from ethylacetate the desired compound was obtained (m.p. 163°-166° C.).

1. temperaturewas cooled to 5°-10° C
2. temperatureThe mixture was maintained
3. temperaturecool
4. stirringwas stirred for a further four hours
5. filtrationthe precipitate was filtered
6. customAfter recrystallization from ethylacetate the desired compound
7. customwas obtained (m.p. 163°-166° C.)