反应详情

A mixture consisting of the product of Example 20 (1.52 g), dimethylamine hydrochloride (565 mg), paraformaldehyde (238 mg) and ethanol (10 ml) was refluxed for four hrs. After cooling to room temperature, the solvent was evaporated under reduced pressure. The residue was dissolved in chloroform, the solution washed four times with 5% aqueous potassium carbonate, dried over Na2SO4 and then the solvent was evaporated on a rotary evaporator. The residue was chromatographed on silica gel, eluting with acetone, to obtain the title compound (m.p. 68°-70° C.).

1. temperaturewas refluxed for four hrs
2. customthe solvent was evaporated under reduced pressure
3. dissolutionThe residue was dissolved in chloroform
4. washthe solution washed four times with 5% aqueous potassium carbonate
5. dry with materialdried over Na2SO4
6. customthe solvent was evaporated on a rotary evaporator
7. customThe residue was chromatographed on silica gel
8. washeluting with acetone