1-Chloro-2-isothiocyanatobenzene → 1-Piperazinecarbothioamide, N-(2-chlorophenyl)-4-pyrazinyl-

HRID 544485Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 544485
[N:1]1[CH:6]=[CH:5][N:4]=[CH:3][C:2]=1[N:7]1[CH2:12][CH2:11][NH:10][CH2:9][CH2:8]1.[Cl:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=1[N:20]=[C:21]=[S:22]>CCOCC>[Cl:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=1[NH:20][C:21]([N:10]1[CH2:9][CH2:8][N:7]([C:2]2[CH:3]=[N:4][CH:5]=[CH:6][N:1]=2)[CH2:12][CH2:11]1)=[S:22]

Komponenten

4

Edukt 2

HCID 1231711-Chloro-2-isothiocyanatobenzeneHCID 27346391-Piperazinylpyrazine

Produkt 1

HCID 34820071-Piperazinecarbothioamide, N-(2-chlorophenyl)-4-pyrazinyl-

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3283Diethyl EtherLösungsmittel2×

Versuchsvorschrift

To a solution of 4.92 g. of 1-(2-pyrazinyl)piperazine in 50 ml. of anhydrous ether is added dropwise a solution of 5.08 g. of 2-chlorophenyl isothiocyanate in 50 ml. of anhydrous ether over 5 minutes. The mixture isstirred for 30 minutes and the resulting solid is collected. This solid is recrystallized from 430 ml. of ethanol giving 7.41 g. of the desired product, m.p. 167°-169° C.

Aufarbeitung

  1. customthe resulting solid is collected
  2. customThis solid is recrystallized from 430 ml

Quellen und Nachweise

ORD-Eintrag
ord-51941cb2b5e9456fbcfdbcdc06c7b010
Quelldatensatz
uspto-grants-1984_05
Patentnummer
US04450272

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