1-Chloro-2-isothiocyanatobenzene → 1-Piperazinecarbothioamide, N-(2-chlorophenyl)-4-pyrazinyl-

Beteiligte Stoffe

Reaktionsschritte

To a solution of 4.92 g. of 1-(2-pyrazinyl)piperazine in 50 ml. of anhydrous ether is added dropwise a solution of 5.08 g. of 2-chlorophenyl isothiocyanate in 50 ml. of anhydrous ether over 5 minutes. The mixture isstirred for 30 minutes and the resulting solid is collected. This solid is recrystallized from 430 ml. of ethanol giving 7.41 g. of the desired product, m.p. 167°-169° C.

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