4-Fluorophenyl isothiocyanate → HCID 20459209, compound

HRID 544487Notes

Reaction equation

HRID 544487 reaction equation
N1C=CN=CC=1[N:7]1[CH2:12][CH2:11][NH:10][CH2:9][CH2:8]1.[F:13][C:14]1[CH:19]=[CH:18][C:17]([N:20]=[C:21]=[S:22])=[CH:16][CH:15]=1>CCOCC>[F:13][C:14]1[CH:19]=[CH:18][C:17]([NH:20][C:21]([N:7]2[CH2:12][CH2:11][NH:10][CH2:9][CH:8]2[C:9]2[CH:8]=[N:7][CH:12]=[CH:11][N:10]=2)=[S:22])=[CH:16][CH:15]=1

Participants

4

Reactant 2

HCID 152414-Fluorophenyl isothiocyanateHCID 27346391-Piperazinylpyrazine

Product 1

HCID 20459209HCID 20459209, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent2×

Procedure

To a solution of 4.92 g. of 1-(2-pyrazinyl)piperazine in 50 ml. of anhydrous ether is added dropwise a solution of 4.59 g. of 4-fluorophenyl isothiocyanate in 50 ml. of anhydrous ether with stirring. Stirring is continued for 30 minutes and the resulting solid is collected. This solid is dissolved in a mixture of 200 ml. of ethanol, and 75 ml. of acetone with heat, then concentrated to 200 ml. and cooled giving 7.43 g. of the desired product as a white solid, m.p. 195°-197° C.

Workup

  1. customthe resulting solid is collected
  2. dissolutionThis solid is dissolved in a mixture of 200 ml
  3. temperatureof acetone with heat
  4. concentrationconcentrated to 200 ml
  5. temperatureand cooled
  6. customgiving 7.43 g

Sources & evidence

ORD record
ord-a2de3aa27df64e2c883f2ce94bd85e72
Source dataset
uspto-grants-1984_05
Patent number
US04450272

Reaction notes

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