4-Fluorophenyl isothiocyanate → HCID 20459209, compound

Participants

Reaction Steps

To a solution of 4.92 g. of 1-(2-pyrazinyl)piperazine in 50 ml. of anhydrous ether is added dropwise a solution of 4.59 g. of 4-fluorophenyl isothiocyanate in 50 ml. of anhydrous ether with stirring. Stirring is continued for 30 minutes and the resulting solid is collected. This solid is dissolved in a mixture of 200 ml. of ethanol, and 75 ml. of acetone with heat, then concentrated to 200 ml. and cooled giving 7.43 g. of the desired product as a white solid, m.p. 195°-197° C.

Provenance & Evidence