Ethyl isothiocyanate → N-Ethyl-4-(6-methoxypyrazin-2-yl)piperazine-1-carbothioamide

HRID 544489Notes

Reaction equation

HRID 544489 reaction equation
[CH3:1][O:2][C:3]1[N:8]=[C:7]([N:9]2[CH2:14][CH2:13][NH:12][CH2:11][CH2:10]2)[CH:6]=[N:5][CH:4]=1.[CH2:15]([N:17]=[C:18]=[S:19])[CH3:16]>CCOCC>[CH2:15]([NH:17][C:18]([N:12]1[CH2:13][CH2:14][N:9]([C:7]2[CH:6]=[N:5][CH:4]=[C:3]([O:2][CH3:1])[N:8]=2)[CH2:10][CH2:11]1)=[S:19])[CH3:16]

Participants

4

Reactant 2

HCID 10966Ethyl isothiocyanateHCID 133186982-Methoxy-6-(piperazin-1-yl)pyrazine

Product 1

HCID 13318699N-Ethyl-4-(6-methoxypyrazin-2-yl)piperazine-1-carbothioamide

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent2×

Procedure

To a solution of 1.94 g. of 1-(6-methoxypyrazinyl)piperazine in 25 ml. of anhydrous ether is added dropwise a solution of 0.87 g. of ethylisothiocyanate in 25 ml. of anhydrous ether. The mixture is stirred 30 minutes and the solid collected and recrystallized from 80% ethanol, giving 2.27 g. of the desired product as white crystals, m.p. 120°-122° C.

Workup

  1. customthe solid collected
  2. customrecrystallized from 80% ethanol
  3. customgiving 2.27 g

Sources & evidence

ORD record
ord-b4be1bf0789641648b4f5822d96edc28
Source dataset
uspto-grants-1984_05
Patent number
US04450272

Reaction notes

Loading…