HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl isothiocyanate → N-Ethyl-4-(6-methoxypyrazin-2-yl)piperazine-1-carbothioamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl isothiocyanate | HCID 10966 | — |
| Reactant | 2-Methoxy-6-(piperazin-1-yl)pyrazine | HCID 13318698 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | N-Ethyl-4-(6-methoxypyrazin-2-yl)piperazine-1-carbothioamide | HCID 13318699 | — |
Reaction Steps
To a solution of 1.94 g. of 1-(6-methoxypyrazinyl)piperazine in 25 ml. of anhydrous ether is added dropwise a solution of 0.87 g. of ethylisothiocyanate in 25 ml. of anhydrous ether. The mixture is stirred 30 minutes and the solid collected and recrystallized from 80% ethanol, giving 2.27 g. of the desired product as white crystals, m.p. 120°-122° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04450272 |
| Source dataset | uspto-grants-1984_05 |
| ORD ID | ord-b4be1bf0789641648b4f5822d96edc28 |
| Source note | uspto-grants-1984_05 |