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2-Fluorophenyl isothiocyanate → 2'-Fluoro-4-(2-pyrazinyl)-1-piperazinethiocarboxanilide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Fluorophenyl isothiocyanate | HCID 97520 | — |
| 反応物 | 1-Piperazinylpyrazine | HCID 2734639 | — |
| 溶媒 | Diethyl Ether | HCID 3283 | — |
| 生成物 | 2'-Fluoro-4-(2-pyrazinyl)-1-piperazinethiocarboxanilide | HCID 13318694 | — |
反応手順
To a solution of 4.92 g. of 1-(2-pyrazinyl)piperazine in 50 ml. of anhydrous ether is added a solution of 4.59 g. of 2-fluorophenyl isothiocyanate in 50 ml. of anhydrous ether over a period of 10 minutes. The mixture is stirred for 30 minutes and the resulting solid is collectedand then recrystallized from 200 ml. of ethanol, giving 7.04 g. of the desired product, m.p. 151°-153° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04450272 |
| 出典データセット | uspto-grants-1984_05 |
| ORD ID | ord-b8ccbe605ef04daf82a06593a3331c0c |
| 出典メモ | uspto-grants-1984_05 |