Dicyclohexylamine → Dicyclohexylamine

Participants

Reaction Steps

A solution of 1.4 g of potassium carbonate in 30 ml of water is added to 2.8 g of 3-(3-bromo-2-methylpropionyl)-4(R)-thiazolidinecarboxylic acid whereupon 3 g of potassium 4-chloro-3-sulfamoyl-thiobenzoate is added slowly under ice-cooling and stirring, and the resulting mixture is stirred at room temperature for 4 hours. The reaction mixture is then treated in an analogous manner of Example 1, and the oily residue thus obtained is converted in a conventional manner into the dicyclohexylamine salt. Thus is obtained dicyclohexylamine salt of 3-[3-(4-chloro-3-sulfamoylbenzoylthio)-2(S)-methylpropionyl]-4(R)-thiazolidinecarboxylic acid as white crystalline powder, melting at 173°-176° C. (recrystallized twice from isopropanol).

Provenance & Evidence