Ammonia → 3-(1H-imidazol-1-yl)propan-1-ol

Participants

Reaction Conditions

Reaction Steps

A mixture of 75 parts of 3-amino-propan-1-ol and 170 parts of 10% strength aqueous ammonia, and a mixture of 145 parts of 40% strength aqueous glyoxal solution and 75 parts of 40% strength aqueous formaldehyde solution, are simultaneously added dropwise, over 30 minutes, to 100 partsof water, whilst stirring, at 70° C. After stirring for a further 30minutes at 70° C., the mixture is worked up by distillation. 77.8 parts of 1-(3-hydroxy-prop-1-yl)-imidazole (boiling point 154°/1 mmHg), corresponding to 61.7% of theory, are obtained.

Provenance & Evidence