Ammonia → 3-(1H-imidazol-1-yl)propan-1-ol
Reaction equation
[NH2:1][CH2:2][CH2:3][CH2:4][OH:5].[NH3:6].[CH:7]([CH:9]=O)=O.[CH2:11]=O>O>[OH:5][CH2:4][CH2:3][CH2:2][N:1]1[CH:9]=[CH:7][N:6]=[CH:11]1Participants
6
Reactant 4
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 70 °C
Procedure
A mixture of 75 parts of 3-amino-propan-1-ol and 170 parts of 10% strength aqueous ammonia, and a mixture of 145 parts of 40% strength aqueous glyoxal solution and 75 parts of 40% strength aqueous formaldehyde solution, are simultaneously added dropwise, over 30 minutes, to 100 partsof water, whilst stirring, at 70° C. After stirring for a further 30minutes at 70° C., the mixture is worked up by distillation. 77.8 parts of 1-(3-hydroxy-prop-1-yl)-imidazole (boiling point 154°/1 mmHg), corresponding to 61.7% of theory, are obtained.
Workup
- stirringAfter stirring for a further 30minutes at 70° C.
- distillationthe mixture is worked up by distillation
Sources & evidence
- ORD record
- ord-00af82ac99df43e6b1252b52a512555a
- Source dataset
- uspto-grants-1984_05
- Patent number
- US04450277
Reaction notes
Loading…