Methanol → HCID 15586992, compound

HRID 544527Notes

Reaction equation

HRID 544527 reaction equation
[CH3:1][N:2]1[C:7](SC)=[N:6][C:5](=[O:10])[C:4]([C:11]2[CH:16]=[CH:15][C:14]([CH3:17])=[CH:13][CH:12]=2)=[N:3]1.[Na].[CH3:19][OH:20]>>[CH3:1][N:2]1[C:7]([O:20][CH3:19])=[N:6][C:5](=[O:10])[C:4]([C:11]2[CH:16]=[CH:15][C:14]([CH3:17])=[CH:13][CH:12]=2)=[N:3]1

Participants

4

Reactant 3

HCID 887MethanolHCID 5360545SodiumHCID 12831832HCID 12831832, compound

Product 1

HCID 15586992HCID 15586992, compoundYield 86%

Procedure

2-Methyl-3-methylthio-6-(p-methylphenyl)-5-oxo-2,5-dihydro-1,2,4-triazine (1.0 g) was added in a solution of metallic sodium (0.1 g) in methanol (10 ml), and the resultant mixture was stirred at room temperature for 2 hours. After stirring, the resulting mixture was evaporated to dryness to give a crude product. Recrystallization of the crude product from acetone gave 0.8 g of 2-methyl-3-methoxy-6-(p-methylphenyl)-5-oxo-2,5-dihydro-1,2,4-triazine in 86% yield. M.P., 159° C.

Workup

  1. customthe resulting mixture was evaporated to dryness
  2. customto give a crude product
  3. customRecrystallization of the crude product from acetone

Sources & evidence

ORD record
ord-66a326d3f4384a6c835854ea901243f8
Source dataset
uspto-grants-1984_05
Patent number
US04451283

Reaction notes

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