2-Amino-5-(trifluoromethyl)benzoic acid → 1-ethyl-7-trifluoromethyl-2,3-dihydro-imidazo[2.1-b]quinazolin-5(1H)-one

Participants

Reaction Steps

A solution of 3.6 g. of 1-ethyl-2-methylthioimidazoline, 5.0 g. of 2-amino-5-trifluoromethylbenzoic acid and 50 ml. of dimethylacetamide is refluxed for 24 hours and then the reaction mixture concentrated in vacuo. The residue is dissolved in methylene chloride, washed first with 2 N sodium hydroxide solution and then with water, dried over magnesium sulfate, filtered and chromatographed on silica gel while eluding with methylene chloride to obtain 1-ethyl-7-trifluoromethyl-2,3-dihydro-imidazo[2.1-b]quinazolin-5(1H)-one.

Provenance & Evidence