反应详情

A solution of 3.6 g. of 1-ethyl-2-methylthioimidazoline, 5.0 g. of 2-amino-5-trifluoromethylbenzoic acid and 50 ml. of dimethylacetamide is refluxed for 24 hours and then the reaction mixture concentrated in vacuo. The residue is dissolved in methylene chloride, washed first with 2 N sodium hydroxide solution and then with water, dried over magnesium sulfate, filtered and chromatographed on silica gel while eluding with methylene chloride to obtain 1-ethyl-7-trifluoromethyl-2,3-dihydro-imidazo[2.1-b]quinazolin-5(1H)-one.

1. concentrationthe reaction mixture concentrated in vacuo
2. dissolutionThe residue is dissolved in methylene chloride
3. washwashed first with 2 N sodium hydroxide solution
4. dry with materialwith water, dried over magnesium sulfate
5. filtrationfiltered
6. customchromatographed on silica gel