Ammonia → 1-(4-Hydroxybutyl)-3-[2-(2,2,2-trifluoroethyl)guanidino]pyrazole

HRID 544559Notes

Reaction equation

HRID 544559 reaction equation
[OH:1][CH2:2][CH2:3][CH2:4][CH2:5][N:6]1[CH:10]=[CH:9][C:8]([NH:11][C:12]([NH:14][CH2:15][C:16]([F:19])([F:18])[F:17])=S)=[N:7]1.[NH3:20]>>[OH:1][CH2:2][CH2:3][CH2:4][CH2:5][N:6]1[CH:10]=[CH:9][C:8]([NH:11][C:12]([NH2:20])=[N:14][CH2:15][C:16]([F:19])([F:18])[F:17])=[N:7]1

Participants

3

Reactant 2

HCID 222AmmoniaHCID 53745325HCID 53745325, compound

Product 1

HCID 204513041-(4-Hydroxybutyl)-3-[2-(2,2,2-trifluoroethyl)guanidino]pyrazoleYield 82%

Procedure

Yellow mercuric oxide (30.1 g.) was added quickly to a stirred solution of 1-(4-hydroxybutyl)-3-[3-(2,2,2-trifluoroethyl)thioureido]pyrazole (10.4 g.) in methanolic ammonia (5 M; 340 ml.). After stirring for 3 hours at room temperature, the reaction mixture was filtered through diatomaceous earth and the filtrate evaporated to dryness in vacuo to give 1-(4-hydroxybutyl)-3-[2-(2,2,2-trifluoroethyl)guanidino]pyrazole, m.p. 105°-106° (yield 82%).

Workup

  1. filtrationthe reaction mixture was filtered through diatomaceous earth
  2. customthe filtrate evaporated to dryness in vacuo

Sources & evidence

ORD record
ord-bb8531bd933145ff8c80f3eebe067fc2
Source dataset
uspto-grants-1984_05
Patent number
US04451463

Reaction notes

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