Ammonia → 1-(4-Hydroxybutyl)-3-[2-(2,2,2-trifluoroethyl)guanidino]pyrazole

Participants

Reaction Steps

Yellow mercuric oxide (30.1 g.) was added quickly to a stirred solution of 1-(4-hydroxybutyl)-3-[3-(2,2,2-trifluoroethyl)thioureido]pyrazole (10.4 g.) in methanolic ammonia (5 M; 340 ml.). After stirring for 3 hours at room temperature, the reaction mixture was filtered through diatomaceous earth and the filtrate evaporated to dryness in vacuo to give 1-(4-hydroxybutyl)-3-[2-(2,2,2-trifluoroethyl)guanidino]pyrazole, m.p. 105°-106° (yield 82%).

Provenance & Evidence