Ammonia → HCID 20458236, compound

HRID 544568Notes

Reaction equation

HRID 544568 reaction equation
[CH2:1]([O:8][CH2:9][CH2:10][CH2:11][C:12]1[N:17]=[C:16]([NH:18][C:19]([NH:21][CH2:22][C:23]([F:26])([F:25])[F:24])=S)[CH:15]=[CH:14][N:13]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH3:27]>>[CH2:1]([O:8][CH2:9][CH2:10][CH2:11][C:12]1[N:17]=[C:16]([NH:18][C:19]([NH2:27])=[N:21][CH2:22][C:23]([F:26])([F:25])[F:24])[CH:15]=[CH:14][N:13]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 222AmmoniaHCID 53717765HCID 53717765, compound

Product 1

HCID 20458236HCID 20458236, compound

Procedure

This thiourea was stirred for 18 hours with yellow mercuric oxide (10 g.) in methanolic ammonia (250 ml.). The mixture was filtered, the filtrate was evaporated to dryness and the residue was extracted with hot CH2Cl2. Evaporation of the CH2Cl2 solution gave 2-(3-benzyloxypropyl)-4-[2-(2,2,2-trifluoroethyl)guanidino]pyrimidine (9.2 g.) which was used without further purification.

Workup

  1. filtrationThe mixture was filtered
  2. customthe filtrate was evaporated to dryness
  3. extractionthe residue was extracted with hot CH2Cl2
  4. customEvaporation of the CH2Cl2 solution

Sources & evidence

ORD record
ord-bc2857eff2bd4e5185ad40b7a3b9d5cb
Source dataset
uspto-grants-1984_05
Patent number
US04451463

Reaction notes

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