3-Chloro-1-propanol → HCID 178509295, compound

HRID 544572Notes

Reaction equation

HRID 544572 reaction equation
[NH2:1][C:2]1[N:6]=[C:5]([SH:7])[NH:4][N:3]=1.[OH-].[Na+].Cl[CH2:11][CH2:12][CH2:13][OH:14]>>[NH2:1][C:2]1[N:6]=[C:5]([S:7][CH2:11][CH2:12][CH2:13][OH:14])[NH:4][N:3]=1

Participants

4

Reactant 3

HCID 123133-Chloro-1-propanolHCID 14798Sodium HydroxideHCID 1785092965-amino-1H-1,2,4-triazole-3-thiol

Product 1

HCID 178509295HCID 178509295, compoundYield 66.1%

Procedure

A mixture of 3-amino-5-mercapto-1,2,4-triazole (1.16 g.), 2 N aqueous sodium hydroxide (6 ml.) and 3-chloropropanol (1.1 g.) was heated at 90° for 1 hour and then cooled. The white solid which crystallised was collected to give 3-amino-5-(3-hydroxypropylthio)-1,2,4-triazole (1.15 g.), m.p. 136°-137°.

Workup

  1. temperaturewas heated at 90° for 1 hour
  2. temperaturecooled
  3. customThe white solid which crystallised
  4. customwas collected

Sources & evidence

ORD record
ord-077fdaa1d40d4b75b40df01c3fa13dae
Source dataset
uspto-grants-1984_05
Patent number
US04451463

Reaction notes

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