Bromodiphenylmethane → HCID 20458406, compound

HRID 544586Notes

Reaction equation

HRID 544586 reaction equation
[CH3:1][N:2]1[CH2:9][CH:8]2[CH:10]([OH:11])[CH:4]([CH2:5][N:6]([CH3:12])[CH2:7]2)[CH2:3]1.[CH:13](Br)([C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1.[C:27]([O-:34])(=[O:33])/[CH:28]=[CH:29]/[C:30]([O-:32])=[O:31]>CO>[C:27]([OH:34])(=[O:33])/[CH:28]=[CH:29]/[C:30]([OH:32])=[O:31].[CH3:12][N:6]1[CH2:5][CH:4]2[CH:10]([O:11][CH:13]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)[C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)[CH:8]([CH2:9][N:2]([CH3:1])[CH2:3]2)[CH2:7]1

Participants

5

Reactant 3

HCID 236603BromodiphenylmethaneHCID 5460307FumarateHCID 123608323,7-Dimethyl-3,7-diazabicyclo[3.3.1]nonan-9-ol

Product 1

HCID 20458406HCID 20458406, compoundYield 50%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

10 g of 3,7-dimethyl-3,7-diazabicyclo[3.3.1]nonane-9-ol are reacted with 24.7 g of benzhydryl bromide as described in Example 1. The product is converted into its fumarate, the salt is dissolved in methanol, and precipitated with methylethyl-ketone. 3,7-Dimethyl-9-benzhydryloxy-3,7-diazabicyclo[3.3.1]nonane fumarate is obtained with a yield of 50%; m.p.: 200°-201° C.

Workup

  1. customprecipitated with methylethyl-ketone

Sources & evidence

ORD record
ord-68b15cd5e2294595a940f6ff25d322a7
Source dataset
uspto-grants-1984_05
Patent number
US04451473

Reaction notes

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