反应详情

To a solution of 5-[2-(hydroxy)ethylthio]imidazo[1,2-a]pyridine (971 mg, 5 mmoles) and trietylamine (0.91 ml, 6.53 mmoles) in methylene chloride (40 ml) was added methyl isocyanate (0.65 ml, 11 mmoles) under ice-cooling with stirring and the mixture was stirred at room temperature for 12 hours. The reaction mixture was washed with saturated saline and dried over anhydrous magnesium sulfater. After the solvent was distilled off, the residue was purified by column chromatography (eluent: methanol/chloroform=1:20) to obtain 1.07 g of the desired product (85.2%, colorless crystals).

1. temperaturecooling
2. stirringthe mixture was stirred at room temperature for 12 hours
3. washThe reaction mixture was washed with saturated saline
4. dry with materialdried over anhydrous magnesium sulfater
5. distillationAfter the solvent was distilled off
6. customthe residue was purified by column chromatography (eluent: methanol/chloroform=1:20)