Isopropanol → Isopropyl 4-[7-(3-methylisoxazol-5-yl)heptoxy]benzoate

HRID 544611Notes

Reaction equation

[C:1]([C:4]1[CH:23]=[CH:22][C:7]([O:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][C:16]2[O:20][N:19]=[C:18]([CH3:21])[CH:17]=2)=[CH:6][CH:5]=1)([OH:3])=[O:2].[CH:24](O)([CH3:26])[CH3:25]>>[CH:24]([O:2][C:1]([C:4]1[CH:5]=[CH:6][C:7]([O:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][C:16]2[O:20][N:19]=[C:18]([CH3:21])[CH:17]=2)=[CH:22][CH:23]=1)=[O:3])([CH3:26])[CH3:25]

Participants

Reactant 2

HCID 3776Isopropanol

HCID 52712095-[7-(4-Carboxyphenoxy)heptyl]-3-methylisoxazole

Product 1

HCID 5271193Isopropyl 4-[7-(3-methylisoxazol-5-yl)heptoxy]benzoate

Procedure

[I; R is CH3, n is 7, X is O, Ar is 4--(CH3)2CHOOCC6H4 ], m.p. 45°-46° C., from 5-[7-(4-carboxyphenoxy)heptyl]-3-methylisoxazole (Example 16) and isopropyl alcohol; MIC vs. rhinovirus Type 2 in vitro=0.23 μg/ml.

Sources & evidence

ORD record: ord-5ef8e093372941e39c70ce81c084161f
Source dataset: uspto-grants-1984_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04451476

Reaction notes

Loading…