Hydrochloric Acid → 3-Amino-1-(3,4-dichlorophenyl)-2-pyrazoline hydrochloride

HRID 544636Notes

Reaction equation

HRID 544636 reaction equation
[NH2:1][C:2]1[CH2:6][CH2:5][N:4]([C:7]2[CH:12]=[CH:11][C:10]([Cl:13])=[C:9]([Cl:14])[CH:8]=2)[N:3]=1.Cl>CO>[ClH:13].[NH2:1][C:2]1[CH2:6][CH2:5][N:4]([C:7]2[CH:12]=[CH:11][C:10]([Cl:13])=[C:9]([Cl:14])[CH:8]=2)[N:3]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 155806881-(3,4-Dichlorophenyl)-4,5-dihydro-1H-pyrazol-3-amine

Product 1

HCID 204584513-Amino-1-(3,4-dichlorophenyl)-2-pyrazoline hydrochloride

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A 1.65 g. amount of 3-amino-1-(3,4-dichlorophenyl)-2-pyrazoline (prepared as described in Example 2) is dissolved in 5.0 ml. of concentrated hydrochloric acid then methanol is added and the solvents are evaporated in vacuo. The residue is triturated with ether several times then acetone is added to crystallize the product. The product of the Example is collected by filtration and washed with ether to give 1.65 g. as colorless crystals, m.p. 170°-175° C. (dec.).

Workup

  1. customthe solvents are evaporated in vacuo
  2. customThe residue is triturated with ether several times
  3. additionacetone is added
  4. customto crystallize the product
  5. washwashed with ether
  6. customto give 1.65 g

Sources & evidence

ORD record
ord-165fad7e24db438dab672c501b9ea300
Source dataset
uspto-grants-1984_05
Patent number
US04451479

Reaction notes

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