Formamide → HCID 12637268, compound

HRID 544652Notes

Reaction equation

HRID 544652 reaction equation
P12(SP3(SP(SP(S3)(S1)=S)(=S)S2)=S)=[S:2].Br[CH:16]([C:27]1[CH:32]=[CH:31][C:30]([O:33][CH3:34])=[CH:29][CH:28]=1)[C:17]([C:19]1[CH:24]=[CH:23][C:22]([O:25][CH3:26])=[CH:21][CH:20]=1)=O.[OH-].[Na+].[CH:37]([NH2:39])=O>C1C=CC=CC=1>[CH3:26][O:25][C:22]1[CH:23]=[CH:24][C:19]([C:17]2[N:39]=[CH:37][S:2][C:16]=2[C:27]2[CH:32]=[CH:31][C:30]([O:33][CH3:34])=[CH:29][CH:28]=2)=[CH:20][CH:21]=1

Participants

6

Reactant 4

HCID 713FormamideHCID 14798Sodium HydroxideHCID 14817Phosphorus sulfide (P2S5)HCID 3441532-Bromo-1,2-bis(4-methoxyphenyl)ethanone

Product 1

HCID 12637268HCID 12637268, compound

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

7 g of phosphorus pentasulphide in 20 ml of formamide are added to a solution of 7 g of 2-bromo-1,2-bis-(p-methoxyphenyl)-ethanone in 20 ml of benzene and the mixture is heated at the boil for 1 hour. It is allowed to cool, neutralised with 10% strength sodium hydroxide solution and extracted by shaking with chloroform. The organic phase is removed, washed with water, dried over magnesium sulphate and concentrated by evaporation. 4,5-bis-(p-methoxyphenyl)-thiazole having a melting point of 98°-99° is obtained, which can be used without further purification.

Workup

  1. temperaturethe mixture is heated at the boil for 1 hour
  2. temperatureto cool
  3. extractionextracted
  4. customThe organic phase is removed
  5. washwashed with water
  6. dry with materialdried over magnesium sulphate
  7. concentrationconcentrated by evaporation

Sources & evidence

ORD record
ord-87d1a681bc3c4c6c8902cfff95e5ca46
Source dataset
uspto-grants-1984_05
Patent number
US04451471

Reaction notes

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