Formamide → HCID 12637268, compound

Participants

Reaction Steps

7 g of phosphorus pentasulphide in 20 ml of formamide are added to a solution of 7 g of 2-bromo-1,2-bis-(p-methoxyphenyl)-ethanone in 20 ml of benzene and the mixture is heated at the boil for 1 hour. It is allowed to cool, neutralised with 10% strength sodium hydroxide solution and extracted by shaking with chloroform. The organic phase is removed, washed with water, dried over magnesium sulphate and concentrated by evaporation. 4,5-bis-(p-methoxyphenyl)-thiazole having a melting point of 98°-99° is obtained, which can be used without further purification.

Provenance & Evidence