反应详情

12.4 g of palladium-on-carbon are added to a solution of 132.9 g (0.759 mole) of 4-methyl-3-nitro-anisole in 1.1 liters of methanol and hydrogenation is carried out at room temperature. The catalyst is filtered off and the filtrate is concentrated in a vacuum rotary evaporator. Recrystallisation from isopropanol/water yields 3-amino-4-methylanisole having a melting point of 43°-44°.

1. customis carried out at room temperature
2. filtrationThe catalyst is filtered off
3. concentrationthe filtrate is concentrated in a vacuum rotary evaporator
4. customRecrystallisation from isopropanol/water