Formic Acid → HCID 178518000, Verbindung

HRID 544740Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 544740
[F:1][C:2]1[N:7]=[C:6]([NH:8][NH:9][C:10]([NH2:12])=[O:11])[CH:5]=[CH:4][CH:3]=1.[CH:13](O)=O>>[F:1][C:2]1[N:7]=[C:6]([N:8]2[CH:13]=[N:12][C:10]([OH:11])=[N:9]2)[CH:5]=[CH:4][CH:3]=1

Komponenten

3

Edukt 2

HCID 284Formic AcidHCID 1478413[(6-Fluoropyridin-2-yl)amino]urea

Produkt 1

HCID 178518000HCID 178518000, VerbindungAusbeute 60 %

Versuchsvorschrift

A solution was prepared by admixing 17 g (0.10 m) of 2-(6-fluoro-2-pyridinyl)hydrazinecarboxamide and 60 mls of 98 percent formic acid. This mixture was stirred and reflux for 2 hours and allowed to cool to room temperature. The insolubles were filtered off and dried to produce 3.5 g of the desired 1-(6-fluoro-2-pyridinyl)-1H-1,2,4-triazol-3-ol which melted at 290° C. with decomposition. The excess formic acid in the remaining liquid phase was distilled off under reduced pressure and the solids which precipitated were washed and dried. This product was a second crop of the desired product which also melted at 290° C. The product was recovered in a yield of 60 percent of theoretical and upon analysis, was found to have carbon, hydrogen and nitrogen contents of 46.80, 2.89 and 31.17 percent, respectively, as compared with the theoretical contents of 46.47, 2.80 and 31.10 percent, respectively, as calculated for the above named compound.

Aufarbeitung

  1. customA solution was prepared
  2. temperaturereflux for 2 hours
  3. filtrationThe insolubles were filtered off
  4. customdried

Quellen und Nachweise

ORD-Eintrag
ord-997e7c64315a41f3ab0115aa3e5a708f
Quelldatensatz
uspto-grants-1984_05
Patentnummer
US04451653

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