Benzoyl chloride → HCID 13091772, compound

HRID 544747Notes

Reaction equation

HRID 544747 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[NH:7][NH:8][C:9]([NH2:11])=[O:10].C(N(CC)CC)C.[C:19](Cl)(=[O:26])[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1>C(#N)C>[C:19]([N:7]([C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][N:1]=1)[NH:8][C:9]([NH2:11])=[O:10])(=[O:26])[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1

Participants

5

Reactant 3

HCID 7412Benzoyl chlorideHCID 8471TriethylamineHCID 1336606580714-38-1

Product 1

HCID 13091772HCID 13091772, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent2×

Procedure

A mixture was prepared by admixing 15.22 g (0.1 mole) of 2-(2-pyridinyl)hydrazinecarboxamide with a solution of 16.2 g (0.16 m) of triethylamine in 200 ml of acetonitrile. The mixture was stirred while a solution of 21.08 g (0.15 m) of benzoyl chloride in 50 ml of acetonitrile was added. After an induction period of ~5 minutes, the mixture exothermed reaching a peak temperature of 52° C. after 10 minutes. The reaction mixture was then stirred, without heating, for 51/2 hours and then heated under reflux for 2 hours. The mixture was cooled and the crude solid 2-benzoyl-2-(2-pyridinyl)hydrazinecarboxamide product was collected by filtration. The product was washed with water and air dried and recovered in a yield of 6.1 g (24 percent of theoretical). The product was recrystallized from methanol and melted at 206° C. and upon analysis, the product was found to have carbon, hydrogen and nitrogen contents of 60.53, 4.62 and 21.47 percent, respectively, as compared with the theoretical contents of 60.92, 4.72 and 21.87 percent, respectively, calculated for the above named compound.

Workup

  1. customA mixture was prepared
  2. additionwas added
  3. customAfter an induction period of ~5 minutes
  4. customa peak temperature of 52° C.
  5. customafter 10 minutes
  6. temperaturewithout heating, for 51/2 hours
  7. temperatureheated
  8. temperatureunder reflux for 2 hours
  9. temperatureThe mixture was cooled
  10. filtrationthe crude solid 2-benzoyl-2-(2-pyridinyl)hydrazinecarboxamide product was collected by filtration
  11. washThe product was washed with water and air
  12. customdried
  13. customrecovered in a yield of 6.1 g (24 percent of theoretical)
  14. customThe product was recrystallized from methanol and melted at 206° C. and upon analysis

Sources & evidence

ORD record
ord-398eddd40f2a4bf4832fd5f7e0b5dd2a
Source dataset
uspto-grants-1984_05
Patent number
US04451653

Reaction notes

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