反应详情

To a solution of 5-[2-(amino)ethylthio]imidazo[1,2-a]pyridine (1.93 g, 10 mmoles) and triethylamine (1.53 ml, 11 mmoles) in methylene chloride (30 ml) was added methyl chloroformate (0.77 ml, 10 mmoles) under ice-cooling with stirring and the mixture was stirred at room temperature for 20 minutes. The reaction mixture was washed in turn with an aqueous sodium bicarborate solution and water, dried over anhydrous magnesium sulfate, and then the solvent was distilled off. The residue was purified by column chromatography (eluent: ethanol/ethyl acetate=1:10) to obtain 1.68 g of the desired product (66.9%, colorless crystals).

1. temperaturecooling
2. stirringthe mixture was stirred at room temperature for 20 minutes
3. washThe reaction mixture was washed in turn with an aqueous sodium bicarborate solution and water
4. dry with materialdried over anhydrous magnesium sulfate
5. distillationthe solvent was distilled off
6. customThe residue was purified by column chromatography (eluent: ethanol/ethyl acetate=1:10)